Hydrochloric Acid → Phenol, 4-methoxy-2-nitro-

HRID 261191ノート

反応式

HRID 261191 の反応式
[N+:1]([C:4]1[CH:10]=[C:9]([O:11][CH3:12])[CH:8]=[CH:7][C:5]=1N)([O-:3])=[O:2].[OH-].[Na+].[O:15]=[As]O[As]=O.Cl>O>[CH3:12][O:11][C:9]1[CH:8]=[CH:7][C:5]([OH:15])=[C:4]([N+:1]([O-:3])=[O:2])[CH:10]=1

参加物

6

反応物 4

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 667934-Methoxy-2-nitroanilineHCID 261004Arsenic(III) oxide

生成物 1

HCID 15285Phenol, 4-methoxy-2-nitro-

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

336.4 g of 2-nitro-4-methoxyaniline was refluxed with 200 g of sodium hydroxide and 10 g of arsenic trioxide in 6500 ml of water, for 20 hours. The resulting solution was cooled on an ice-bath, acidified to pH 1 with concentrated hydrochloric acid and filtered. The solid product was washed with water, and dried under vacuum and in the presence of P2O5 to give 4-methoxy-2-nitrophenol (7A), mp: 78°-80° C.

後処理

  1. temperatureThe resulting solution was cooled on an ice-bath
  2. filtrationfiltered
  3. washThe solid product was washed with water
  4. dry with materialdried under vacuum and in the presence of P2O5

出典と根拠

ORDレコード
ord-2814a1a1d504401e9344463b01d1a26f
出典データセット
uspto-grants-1979_08
特許番号
US04164576

反応ノート

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