Sodium Iodide → 2-(2-(2-Iodoethoxy)ethoxy)ethanol

One hundred grams (0.59 mole) of 2-[2-(2-chloroethoxy)ethoxy]-ethanol (Aldrich 16,297-3) was added to a solution of 450 g. (3 mol) of sodium iodide in 2.5 l acetone and stirred, in the dark, for 5 hours at reflux and then at room temperature for 16 hours. The precipitate was filtered and the acetone evaporated off at 30° C. The residue was dissolved in chloroform, extracted with saturated sodium chloride solution, and then with saturated sodium bisulfate solution. The chloroform extract was dried (MgSO4) and evaporated at room temperature to yield 137 g. (53%) of the title compound.

1. temperaturein the dark, for 5 hours at reflux
2. filtrationThe precipitate was filtered
3. customthe acetone evaporated off at 30° C
4. dissolutionThe residue was dissolved in chloroform
5. extractionextracted with saturated sodium chloride solution
6. extractionThe chloroform extract
7. dry with materialwas dried (MgSO4)
8. customevaporated at room temperature
9. customto yield 137 g

ORDレコード

ord-6ede480cd1ed4fee92e5a6d47a006c8b

出典データセット

uspto-grants-1979_08

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US04165334