Sodium Hydroxide → Permethric acid

HRID 261459

反応式

HRID 261459 の反応式
[Cl:1][C:2]([Cl:12])=[CH:3][C@@H:4]1[C@H:6]([C:7]([OH:9])=[O:8])[C:5]1([CH3:11])[CH3:10].[OH-].[Na+]>O>[Cl:1][C:2]([Cl:12])=[CH:3][CH:4]1[CH:6]([C:7]([OH:9])=[O:8])[C:5]1([CH3:10])[CH3:11]

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 41507Cis-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropane carboxylic acid2 回

生成物 1

HCID 91658Permethric acid収率 87%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

Conversion to high cis 3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropane-1-carboxylic acid (compound C acid). Sodium hydroxide (20 g, 0.5 mole) in 100 ml of water was added to the reaction mixture above with vigorous stirring and the whole was heated at 100° for 5 hours under conditions allowing for the distillation of the tert-butanol present from the Phase (a) reaction. The mixture was allowed to cool to room temperature, then washed with ether and made acidic with concentrated hydrochloric acid. The acidified mixture was extracted with ether and the ether extracts were combined, washed with brine, dried over magnesium sulfate and concentrated to give, after distillation, 18.22 g (87% yield) of 3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropane-1-carboxylic acid, bp 102°-105°/0.3 mm Hg, purity 97.3%, C/T=78/22.

後処理

  1. temperaturethe whole was heated at 100° for 5 hours under conditions
  2. distillationallowing for the distillation of the tert-butanol present from the Phase (a) reaction
  3. washwashed with ether
  4. extractionThe acidified mixture was extracted with ether
  5. washwashed with brine
  6. dry with materialdried over magnesium sulfate
  7. concentrationconcentrated
  8. customto give

出典と根拠

ORDレコード
ord-7002097287ca43efa4a95f54092d8121
出典データセット
uspto-grants-1979_08
特許番号
US04166064

関連ノート

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