Htris → 2-(2-Isopropyl-5-indanyl)propionic acid

HRID 261525

反応式

HRID 261525 の反応式
[CH:1]([CH:4]1[CH2:12][C:11]2[C:6](=[CH:7][CH:8]=[C:9]([C:13](=[CH2:17])[C:14]([OH:16])=[O:15])[CH:10]=2)[CH2:5]1)([CH3:3])[CH3:2].OCC([NH3+])(CO)CO>C(O)C.[Pt](=O)=O>[CH:1]([CH:4]1[CH2:12][C:11]2[C:6](=[CH:7][CH:8]=[C:9]([CH:13]([CH3:17])[C:14]([OH:16])=[O:15])[CH:10]=2)[CH2:5]1)([CH3:3])[CH3:2]

参加物

5

反応物 2

HCID 3777159HtrisHCID 542342992-Isopropyl-alpha-methylene-5-indanacetic acid

生成物 1

HCID 687692-(2-Isopropyl-5-indanyl)propionic acid

試薬・触媒・溶媒 2

HCID 345198Adams' catalyst触媒HCID 702Ethanol溶媒

実験手順

A solution of 1.7 g of 2-isopropyl-α-methylene-5-indanacetic acid in 300 cc of ethanol is hydrogenated at room temperature with the addition of 50 mg of platinum(IV) oxide. After filtering off the catalyst, removing the solvent by evaporation and chromatographing the resulting oil, 2-isopropyl-α-methyl-5-indanacetic acid, having a M.P. of 83°-86°, is obtained. The (1,3-dihydroxy-2-hydroxymethyl-2-propyl)ammonium salt of the title compound has a M.P. of 140°-141° (from methanol/ether).

後処理

  1. filtrationAfter filtering off the catalyst
  2. customremoving the solvent
  3. customby evaporation and chromatographing the resulting oil, 2-isopropyl-α-methyl-5-indanacetic acid
  4. customis obtained

出典と根拠

ORDレコード
ord-df1cdc89f3144844b82437d920b8d357
出典データセット
uspto-grants-1979_08
特許番号
US04166131

関連ノート

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