Hydrochloric Acid → 2-Ethyl-2-methyl-indan

HRID 261529

反応式

HRID 261529 の反応式
Cl.[CH2:2]([C:4]1([CH3:14])[CH2:12][C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[C:5]1=O)[CH3:3]>O.C(O)C.[Zn].C([O-])(=O)C.[Hg+2].C([O-])(=O)C>[CH2:2]([C:4]1([CH3:14])[CH2:12][C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[CH2:5]1)[CH3:3]

参加物

7

反応物 2

HCID 313Hydrochloric AcidHCID 146860942-Ethyl-2-methyl-1-indanone

生成物 1

HCID 203944402-Ethyl-2-methyl-indan

試薬・触媒・溶媒 4

HCID 15337Mercuric acetate触媒HCID 23994Zinc触媒HCID 702Ethanol溶媒HCID 962Water溶媒

実験手順

335 g of zinc dust and 33.5 g of mercury (II) acetate and a solution of 330 cc of concentrated hydrochloric acid in 280 cc of water are rapidly added dropwise in a stirring apparatus. The mixture is boiled at reflux and a solution of 63 g of 2-ethyl-2-methyl-1-indanone in 525 cc of ethanol is added dropwise within 10 minutes while stirring. The reaction mixture is subsequently stirred at reflux for 28 hours, cooled, filtered, and the residue is washed with water/petroleum ether. The filtrate is extracted with petroleum ether, the petroleum ether extract is washed with water and dried over sodium sulphate. The crude 2-ethyl-2-methyl-indan, obtained as an oil after evaporating the solvent, is purified by chromatography on aluminium oxide/petroleum ether.

後処理

  1. temperatureat reflux
  2. stirringThe reaction mixture is subsequently stirred
  3. temperatureat reflux for 28 hours
  4. temperaturecooled
  5. filtrationfiltered
  6. washthe residue is washed with water/petroleum ether
  7. extractionThe filtrate is extracted with petroleum ether
  8. extractionthe petroleum ether extract
  9. washis washed with water
  10. dry with materialdried over sodium sulphate

出典と根拠

ORDレコード
ord-28adf486cf104b4d8d97dd240ed54f30
出典データセット
uspto-grants-1979_08
特許番号
US04166131

関連ノート

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