Metaperiodic acid → 3-Chloro-4-cyclohexylbenzaldehyde

HRID 261586

反応式

HRID 261586 の反応式
[Cl:1][C:2]1[CH:3]=[C:4]([CH:14]([OH:17])CO)[CH:5]=[CH:6][C:7]=1[CH:8]1[CH2:13][CH2:12][CH2:11][CH2:10][CH2:9]1.I(O)(=O)(=O)=O>O1CCCC1.CCOCC>[Cl:1][C:2]1[CH:3]=[C:4]([CH:5]=[CH:6][C:7]=1[CH:8]1[CH2:9][CH2:10][CH2:11][CH2:12][CH2:13]1)[CH:14]=[O:17]

参加物

5

反応物 2

HCID 65185Metaperiodic acidHCID 129398511-(3-Chloro-4-cyclohexylphenyl)ethane-1,2-diol

生成物 1

HCID 107277773-Chloro-4-cyclohexylbenzaldehyde

試薬・触媒・溶媒 2

HCID 3283Diethyl Ether溶媒HCID 8028Tetrahydrofuran溶媒

実験手順

To 115 g. of 1-(3-chloro-4-cyclohexylphenyl)-1,2-ethanediol in tetrahydrofuran (800 ml.) is added a solution of periodic acid (102 g.) in ether (750 ml.). The reaction mixture is stirred under nitrogen overnight. The reaction mixture is filtered and the filtrate is washed with water (3×200 ml) and placed over sodium sulfate. Removal of solvent gives a liquid residue which is then distilled to give 3-chloro-4-cyclohexylbenzaldehyde.

後処理

  1. filtrationThe reaction mixture is filtered
  2. washthe filtrate is washed with water (3×200 ml)
  3. customRemoval of solvent
  4. customgives a liquid residue which
  5. distillationis then distilled

出典と根拠

ORDレコード
ord-bd3d48e15ff34669857d860640d41bc3
出典データセット
uspto-grants-1979_08
特許番号
US04166133

関連ノート

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