Potassium thiocyanate → 4-(4-Benzamidobutyl)-5-methylimidazole-2-thione

HRID 261619ノート

反応式

HRID 261619 の反応式
Cl.[NH2:2][CH:3]([CH2:7][CH2:8][CH2:9][CH2:10][NH:11][C:12](=[O:19])[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)[C:4](=O)[CH3:5].[S-:20][C:21]#[N:22].[K+]>O>[C:12]([NH:11][CH2:10][CH2:9][CH2:8][CH2:7][C:3]1[C:4]([CH3:5])=[N:22][C:21](=[S:20])[N:2]=1)(=[O:19])[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1

参加物

4

反応物 2

HCID 516872Potassium thiocyanateHCID 203945683-Amino-7-benzamidoheptan-2-one hydrochloride

生成物 1

HCID 203945574-(4-Benzamidobutyl)-5-methylimidazole-2-thione収率 25.3%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

A solution of 3-amino-7-benzamidoheptan-2-one hydrochloride (16.39 g, 0.0576 mol) and potassium thiocyanate (7.30 g, 0.0755 mol, excess) in water was heated under reflux for 20 hours. The aquesus phase was decanted off and the organic phase was washed with water, and recrystallised from acetonitrile to give 4-(4-benzamidobutyl)-5-methylimidazole-2-thione (4.18 g, 25%) m.p. 180°-184°.

後処理

  1. temperatureunder reflux for 20 hours
  2. customThe aquesus phase was decanted off
  3. washthe organic phase was washed with water
  4. customrecrystallised from acetonitrile

出典と根拠

ORDレコード
ord-d1526fc277ce41089995dc0eceed56f5
出典データセット
uspto-grants-1979_08
特許番号
US04166184

反応ノート

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