Sodium Hydroxide → 2-Methoxyimino-2-(3-chloro-4-hydroxyphenyl)acetic acid

反応式

[CH3:1][O:2][N:3]=[C:4]([C:9]1[CH:14]=[CH:13][C:12]([OH:15])=[C:11]([Cl:16])[CH:10]=1)[C:5]([O:7]C)=[O:6].[OH-].[Na+]>>[CH3:1][O:2][N:3]=[C:4]([C:9]1[CH:14]=[CH:13][C:12]([OH:15])=[C:11]([Cl:16])[CH:10]=1)[C:5]([OH:7])=[O:6]

参加物

反応物 2

HCID 14798Sodium Hydroxide

HCID 136176295Methyl 2-methoxyimino-2-(3-chloro-4-hydroxyphenyl)acetate

生成物 1

HCID 1360939502-Methoxyimino-2-(3-chloro-4-hydroxyphenyl)acetic acid収率 97.9%

実験手順

Methyl 2-methoxyimino-2-(3-chloro-4-hydroxyphenyl)acetate (syn isomer) (2.6 g.) and a 2 N aqueous solution of sodium hydroxide (10.6 ml.) were treated according to a similar manner to that of Preparation (5-3)(c) to give 2-methoxyimino-2-(3-chloro-4-hydroxyphenyl)acetic acid (syn isomer) (2.4 g.), mp 147° to 150° C. (dec.).

出典と根拠

ORDレコード: ord-6817e2b629c6463eb73185e5f28de8c4
出典データセット: uspto-grants-1979_08
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US04166115

反応ノート

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