Ethyl 2-methoxyimino-2-(2-aminothiazol-4-yl)acetate hydrobromide → 2-(2-Aminothiazole-4-yl)-2-methoxyiminoacetic acid

HRID 261693

反応式

HRID 261693 の反応式
Br.[CH3:2][O:3][N:4]=[C:5]([C:11]1[N:12]=[C:13]([NH2:16])[S:14][CH:15]=1)[C:6]([O:8]CC)=[O:7]>[OH-].[Na+].O>[CH3:2][O:3][N:4]=[C:5]([C:11]1[N:12]=[C:13]([NH2:16])[S:14][CH:15]=1)[C:6]([OH:8])=[O:7]

参加物

4

反応物 1

HCID 73668749Ethyl 2-methoxyimino-2-(2-aminothiazol-4-yl)acetate hydrobromide

生成物 1

HCID 1252162-(2-Aminothiazole-4-yl)-2-methoxyiminoacetic acid収率 79.6%

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 14798Sodium Hydroxide溶媒

実験手順

Ethyl 2-methoxyimino-2-(2-amino-1,3-thiazol-4-yl)acetate hydrobromide (anti isomer) (15.5 g.) was dissolved in a solution of sodium hydroxide (4.4 g.) in water (150 ml.) and the resulting solution was stirred for 1 hour at ambient temperature. An insoluble material was filtered off and the filtrate was adjusted to pH 5.0 to precipitate crystals. The crystals were collected by filtration and dried to give 2-methoxyimino-2-(2-amino-1,3-thiazol-4-yl)acetic acid (anti isomer) (8.0 g.).

後処理

  1. filtrationAn insoluble material was filtered off
  2. customto precipitate crystals
  3. filtrationThe crystals were collected by filtration
  4. customdried

出典と根拠

ORDレコード
ord-162180bcda7e45399c4948162554dbeb
出典データセット
uspto-grants-1979_08
特許番号
US04166115

関連ノート

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