Sodium borohydride → N-(o-Chlorobenzyl)-2-methyl-3-chloroaniline

HRID 261823ノート

反応式

HRID 261823 の反応式
[Cl:1][C:2]1[CH:17]=[CH:16][CH:15]=[CH:14][C:3]=1[CH:4]=[N:5][C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([Cl:12])[C:7]=1[CH3:13].[BH4-].[Na+]>CO.O>[Cl:1][C:2]1[CH:17]=[CH:16][CH:15]=[CH:14][C:3]=1[CH2:4][NH:5][C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([Cl:12])[C:7]=1[CH3:13]

参加物

5

反応物 2

HCID 4311764Sodium borohydrideHCID 13017551N-(o-Chlorobenzylidene)-2-methyl-3-chloroaniline

生成物 1

HCID 21321344N-(o-Chlorobenzyl)-2-methyl-3-chloroaniline

試薬・触媒・溶媒 2

HCID 887Methanol溶媒HCID 962Water溶媒

実験手順

A suspension of N-(o-chlorobenzylidene)-2-methyl-3-chloroaniline (0.038 mole) is brought to reflux in 100 cc of absolute methanol. An equivalent of sodium borohydride (1.5 g.) is added in portions and refluxing is continued for 15 mins. The reaction mixture is cooled and diluted with an equal volume of cold water to precipitate a solid. This material is collected, washed with H2O and air dried. Recrystallization from ethanol gives N-(o-Chlorobenzyl)-2-methyl-3-chloroaniline. m.p. 63°-66° C.

後処理

  1. temperaturerefluxing
  2. temperatureThe reaction mixture is cooled
  3. customto precipitate a solid
  4. customThis material is collected
  5. washwashed with H2O and air
  6. customdried
  7. customRecrystallization from ethanol

出典と根拠

ORDレコード
ord-7a8529161f27459898c0d6297c3f8657
出典データセット
uspto-grants-1979_05
特許番号
US04152452

反応ノート

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