Pyridine → alpha-Trifluoromethyl-3-phenoxybenzyl 2-(4-chlorophenyl)-3-methylbutanoate

HRID 261841

反応式

HRID 261841 の反応式
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([CH:12]([CH3:14])[CH3:13])[C:9](Cl)=[O:10])=[CH:4][CH:3]=1.[F:15][C:16]([F:33])([F:32])[CH:17]([OH:31])[C:18]1[CH:23]=[CH:22][CH:21]=[C:20]([O:24][C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=2)[CH:19]=1.N1C=CC=CC=1>C1(C)C=CC=CC=1>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([CH:12]([CH3:14])[CH3:13])[C:9]([O:31][CH:17]([C:16]([F:15])([F:32])[F:33])[C:18]2[CH:23]=[CH:22][CH:21]=[C:20]([O:24][C:25]3[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=3)[CH:19]=2)=[O:10])=[CH:4][CH:3]=1

参加物

5

反応物 3

HCID 1049PyridineHCID 41780012-(4-Chlorophenyl)-3-methylbutanoyl chlorideHCID 142705712,2,2-Trifluoro-1-(3-phenoxyphenyl)ethan-1-ol

生成物 1

HCID 53818390alpha-Trifluoromethyl-3-phenoxybenzyl 2-(4-chlorophenyl)-3-methylbutanoate収率 98.3%

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

This compound was prepared in the manner of Example II, using 5.3 g of 2-(4-chlorophenyl)-3-methylbutanoyl chloride, whose preparation is described in Agr. Biol. Chem., 38, 881 (1974), together with J. Kagaku To Seibutsu, 14, 427 (1976), 4.6 g of α-trifluoromethyl-3-phenoxybenzyl alcohol, and 1.5 g of pyridine in 50 ml of toluene. Volatiles were removed from the crude reaction product at 100° C./0.02 mm through a short path Kugelrohr distillation system to give as a residue 7.8 g of α-trifluoromethyl-3-phenoxybenzyl 2-(4-chlorophenyl)-3-methylbutanoate. The ir spectrum was consistent with the assigned structure.

後処理

  1. customThis compound was prepared in the manner of Example II
  2. customVolatiles were removed from the crude
  3. customreaction product at 100° C./0.02 mm
  4. distillationthrough a short path Kugelrohr distillation system

出典と根拠

ORDレコード
ord-2168c1c5860e41bcbe412bf4e1bd93fc
出典データセット
uspto-grants-1979_05
特許番号
US04152455

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