Acetonitrile → (4-Carboxybutyl)triphenylphosphonium bromide

HRID 261916

反応式

HRID 261916 の反応式
[Br:1][CH2:2][CH2:3][CH2:4][CH2:5][C:6]([OH:8])=[O:7].[C:9]1([P:15]([C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)[C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1.C(#N)C>C1C=CC=CC=1>[Br-:1].[C:6]([CH2:5][CH2:4][CH2:3][CH2:2][P+:15]([C:16]1[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=1)([C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1)[C:9]1[CH:10]=[CH:11][CH:12]=[CH:13][CH:14]=1)([OH:8])=[O:7]

参加物

5

反応物 3

HCID 6342AcetonitrileHCID 11776TriphenylphosphineHCID 163685-Bromovaleric acid

生成物 1

HCID 161236(4-Carboxybutyl)triphenylphosphonium bromide

試薬・触媒・溶媒 1

HCID 241Benzene溶媒

実験手順

A mixture of 103 g. of 5-bromovaleric acid and 152 g. of triphenylphosphine in 400 ml. of acetonitrile is refluxed for 48 hours, cooled, diluted with 100 ml. of benzene and allowed to crystallize. The crystals are filtered, washed with benzene and ether, to yield colorless material, m.p. 207°-209° C.

後処理

  1. additionA mixture of 103 g
  2. temperaturecooled
  3. additiondiluted with 100 ml
  4. customto crystallize
  5. filtrationThe crystals are filtered
  6. washwashed with benzene and ether
  7. customto yield colorless material, m.p. 207°-209° C.

出典と根拠

ORDレコード
ord-ac6a772fb3ad443cbafbec131e02d7b2
出典データセット
uspto-grants-1979_05
特許番号
US04152524

関連ノート

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