Ammonia → alpha,alpha-Bis(p-fluorophenyl)imidazole-2-methanol

HRID 261932

反応式

HRID 261932 の反応式
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([C:25]2[CH:30]=[CH:29][C:28]([F:31])=[CH:27][CH:26]=2)([C:10]2[N:11](S(C3C=CC(C)=CC=3)(=O)=O)[CH:12]=[CH:13][N:14]=2)[OH:9])=[CH:4][CH:3]=1.Cl.N>O>[F:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]([C:25]2[CH:30]=[CH:29][C:28]([F:31])=[CH:27][CH:26]=2)([C:10]2[NH:14][CH:13]=[CH:12][N:11]=2)[OH:9])=[CH:6][CH:7]=1

参加物

5

反応物 3

HCID 222AmmoniaHCID 313Hydrochloric AcidHCID 12433917alpha,alpha-Bis(p-fluorophenyl)-1-(toluene-p-sulphonyl)imidazole-2-methanol

生成物 1

HCID 12433865alpha,alpha-Bis(p-fluorophenyl)imidazole-2-methanol

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

A mixture of 10 g. (0.0227 mol) of α,α-bis(p-fluorophenyl)-1-(toluene-p-sulphonyl)imidazole-2-methanol, 34 ml. of 2 N hydrochloric acid solution (0.0681 mol) and 225 ml. of water was boiled under reflux for 5 hours. After cooling, the mixture was made alkaline by addition of ammonia. The base obtained was crystallised from isopropyl alcohol; its melting point was 198°-200° C.

後処理

  1. additionA mixture of 10 g
  2. temperatureunder reflux for 5 hours
  3. temperatureAfter cooling
  4. customThe base obtained
  5. customwas crystallised from isopropyl alcohol

出典と根拠

ORDレコード
ord-153184a93b154a239bd59302d58b85d5
出典データセット
uspto-grants-1979_05
特許番号
US04152441

関連ノート

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