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Ammonia → alpha,alpha-Bis(p-fluorophenyl)imidazole-2-methanol
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ammonia | HCID 222 | — |
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | alpha,alpha-Bis(p-fluorophenyl)-1-(toluene-p-sulphonyl)imidazole-2-methanol | HCID 12433917 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | alpha,alpha-Bis(p-fluorophenyl)imidazole-2-methanol | HCID 12433865 | — |
反応手順
A mixture of 10 g. (0.0227 mol) of α,α-bis(p-fluorophenyl)-1-(toluene-p-sulphonyl)imidazole-2-methanol, 34 ml. of 2 N hydrochloric acid solution (0.0681 mol) and 225 ml. of water was boiled under reflux for 5 hours. After cooling, the mixture was made alkaline by addition of ammonia. The base obtained was crystallised from isopropyl alcohol; its melting point was 198°-200° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04152441 |
| 出典データセット | uspto-grants-1979_05 |
| ORD ID | ord-153184a93b154a239bd59302d58b85d5 |
| 出典メモ | uspto-grants-1979_05 |