alpha-(p-Bromophenyl)-alpha-phenyl-1-(toluene-p-sulphonyl)imidazole-2-methanol → (2-chlorophenyl)(1H-imidazol-2-yl)phenylmethanol

HRID 261941

反応式

HRID 261941 の反応式
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]([C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1)([C:10]1[N:11](S(C2C=CC(C)=CC=2)(=O)=O)[CH:12]=[CH:13][N:14]=1)[OH:9].BrC1C=CC(C(C2C=CC=CC=2)(C2N(S(C3C=CC(C)=CC=3)(=O)=O)C=CN=2)O)=CC=1>>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]([C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1)([C:10]1[NH:14][CH:13]=[CH:12][N:11]=1)[OH:9]

参加物

3

反応物 2

HCID 11838798alpha-(p-Bromophenyl)-alpha-phenyl-1-(toluene-p-sulphonyl)imidazole-2-methanolHCID 12433918(2-chlorophenyl){1-[(4-methylphenyl)sulfonyl]-1H-imidazol-2-yl}phenylmethanol

生成物 1

HCID 12433860(2-chlorophenyl)(1H-imidazol-2-yl)phenylmethanol

実験手順

Using the procedure described in Example IB but substituting an equivalent amount of α-(o-chlorophenyl)-α-phenyl-1-(toluene-p-sulphonyl)imidazole-2-methanol for the α-(p-bromophenyl)-α-phenyl-1-(toluene-p-sulphonyl)imidazole-2-methanol, α-(o-chlorophenyl)-α-phenylimidazole-2-methanol was obtained. Its melting point was 186°-188° C. after crystallisation from isopropyl alcohol.

出典と根拠

ORDレコード
ord-bfa6a586ef56492db00b25efd266f1ef
出典データセット
uspto-grants-1979_05
特許番号
US04152441

関連ノート

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