HCID 54518938、化合物 → Ethyl (2R)-2,3-dihydroxy-2-methylpropanoate
反応式
C([O:8][C@:9]([CH3:17])([CH2:15][OH:16])[C:10]([O:12][CH2:13][CH3:14])=[O:11])C1C=CC=CC=1.[H][H]>C(OCC)(=O)C.[Pd]>[OH:8][C@:9]([CH3:17])([CH2:15][OH:16])[C:10]([O:12][CH2:13][CH3:14])=[O:11]参加物
5
実験手順
22 g of ethyl (R)-2-benzyloxy-3-hydroxy-2-methyl-propionate (manufactured in accordance with Example 1) in 150 ml of ethyl acetate were hydrogenated with hydrogen gas in the presence of 11 g of 5% by weight palladium/carbon catalyst up to the cessation of the hydrogen uptake. The catalyst was filtered off, washed with ethyl acetate (2×50 ml), the filtrate was concentrated in the vacuum and the residual oil was distilled at 56-57°/0.1 mmHg. There were obtained 12.7 g of ethyl (R)-2,3-dihydroxy-2-methyl-propionate in the form of a colorless viscous liquid. [α]D =+0.339° (undiluted);=+11.6° (c=2.12 in chloroform).
後処理
- filtrationThe catalyst was filtered off
- washwashed with ethyl acetate (2×50 ml)
- concentrationthe filtrate was concentrated in the vacuum
- distillationthe residual oil was distilled at 56-57°/0.1 mmHg
出典と根拠
- ORDレコード
- ord-c582f80c0d44427d912b3871bdd53dc5
- 出典データセット
- uspto-grants-1979_05
- 特許番号
- US04153614
反応ノート
読み込み中…