1-Methylpiperazine → HCID 47864、化合物

HRID 262064ノート

反応式

HRID 262064 の反応式
[C:1]([NH:4][C:5]1[C:6]([O:18][CH2:19][CH2:20]Cl)=[C:7]([O:16][CH3:17])[C:8]2[O:12][CH:11]=[CH:10][C:9]=2[C:13]=1[O:14][CH3:15])(=[O:3])[CH3:2].[CH3:22][N:23]1[CH2:28][CH2:27][NH:26][CH2:25][CH2:24]1>C1(C)C=CC=CC=1>[C:1]([NH:4][C:5]1[C:6]([O:18][CH2:19][CH2:20][N:26]2[CH2:27][CH2:28][N:23]([CH3:22])[CH2:24][CH2:25]2)=[C:7]([O:16][CH3:17])[C:8]2[O:12][CH:11]=[CH:10][C:9]=2[C:13]=1[O:14][CH3:15])(=[O:3])[CH3:2]

参加物

4

反応物 2

HCID 531671-MethylpiperazineHCID 12672371HCID 12672371、化合物

生成物 1

HCID 47864HCID 47864、化合物

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

A solution of 15.5 g (0.05 mole) of 5-acetamido 6-(2-chloro ethoxy) 4,7dimethoxy benzofuran prepared in the preceding example and 15 g (0.15 mole) of N-methyl piperazine was brought to reflux for 8 hours in 100 ml of toluene. It was filtered and the filtrate evaporated under vacum the residue was taken up again in alcohol and hydrochloric alcohol was added. It was filtered and recrystallized in absolute alcohol.

後処理

  1. filtrationIt was filtered
  2. customthe filtrate evaporated under vacum the residue
  3. additionhydrochloric alcohol was added
  4. filtrationIt was filtered
  5. customrecrystallized in absolute alcohol

出典と根拠

ORDレコード
ord-3a2f50e14bf6486990050ba1f006c2ba
出典データセット
uspto-grants-1979_05
特許番号
US04153620

反応ノート

読み込み中…