Methyl iodide → (RS)-3-Methylthio-9,9a-dihydrothiazolo[3,4-a]indolium iodide

HRID 262120ノート

反応式

HRID 262120 の反応式
[CH3:1][I:2].[CH2:3]1[CH:7]2[CH2:8][C:9]3[CH:10]=[CH:11][CH:12]=[CH:13][C:14]=3[N:6]2[C:5](=[S:15])[S:4]1>C(Cl)Cl>[I-:2].[CH3:1][S:15][C:5]1[S:4][CH2:3][CH:7]2[CH2:8][C:9]3[CH:10]=[CH:11][CH:12]=[CH:13][C:14]=3[N+:6]=12

参加物

4

反応物 2

HCID 6328Methyl iodideHCID 21320146(RS)-9,9a-dihydrothiazolo[3,4-a]indole-3-thione

生成物 1

HCID 21320148(RS)-3-Methylthio-9,9a-dihydrothiazolo[3,4-a]indolium iodide

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

反応条件

温度
20 °C

実験手順

Methyl iodide (40 cc) is added to a solution of (RS)-9,9a-dihydrothiazolo[3,4-a]indole-3-thione (30.0 g) in methylene chloride (150 cc). After stirring for 20 hours at about 20° C., the resulting crystals are filtered off, washed with diethyl ether (2×50 cc) and then dried at 20° C. under reduced pressure (20 mm Hg). (RS)-3-Methylthio-9,9a-dihydrothiazolo[3,4-a]indolium iodide (50.2 g), melting at 135°-140° C. with decomposition, is thus obtained.

後処理

  1. filtrationthe resulting crystals are filtered off
  2. washwashed with diethyl ether (2×50 cc)
  3. customdried at 20° C. under reduced pressure (20 mm Hg)

出典と根拠

ORDレコード
ord-f7e1794c2a264129864f9e81cb2d06fb
出典データセット
uspto-grants-1979_05
特許番号
US04153699

反応ノート

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