Water → N-acetyl-3-phenylindoline

HRID 262291ノート

反応式

HRID 262291 の反応式
[C:1]1([CH:7]2[C:15]3[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=3)[NH:9][CH2:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.O.[OH-].[Na+].[C:19](OC(=O)C)(=[O:21])[CH3:20]>>[C:19]([N:9]1[C:10]2[C:15](=[CH:14][CH:13]=[CH:12][CH:11]=2)[CH:7]([C:1]2[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=2)[CH2:8]1)(=[O:21])[CH3:20]

参加物

5

反応物 4

HCID 962WaterHCID 7918Acetic AnhydrideHCID 14798Sodium HydroxideHCID 109323533-phenyl-2,3-dihydro-1H-indole

生成物 1

HCID 15428722N-acetyl-3-phenylindoline

実験手順

1.0 G of 3-phenylindoline was dissolved in 10 ml of acetic anhydride at room temperature. After 10 minutes, the reaction mixture was poured into 100 ml of water, slightly basified with aqueous sodium hydroxide and extracted with methylene chloride. After removal of the methylenechloride, the residue was recrystallized from cyclohexane to give 1.15 g of the desired N-acetyl-3-phenylindoline which was found to have a 106°-7° C.

後処理

  1. extractionextracted with methylene chloride
  2. customAfter removal of the methylenechloride
  3. customthe residue was recrystallized from cyclohexane

出典と根拠

ORDレコード
ord-fd9bb74308fb497badfb14f6bc31f721
出典データセット
uspto-grants-1979_05
特許番号
US04153789

反応ノート

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