Hydrazine hydrate (1:1) → 2-[(4-Methylpiperazin-1-yl)methyl]aniline

HRID 262328

反応式

HRID 262328 の反応式
O.NN.[CH3:4][N:5]1[CH2:10][CH2:9][N:8]([CH2:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=2[N+:18]([O-])=O)[CH2:7][CH2:6]1>C(O)C.[Ni]>[CH3:4][N:5]1[CH2:10][CH2:9][N:8]([CH2:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=2[NH2:18])[CH2:7][CH2:6]1

参加物

5

反応物 2

HCID 24654Hydrazine hydrate (1:1)HCID 7913741-Methyl-4-(2-nitrobenzyl)piperazine

生成物 1

HCID 64845562-[(4-Methylpiperazin-1-yl)methyl]aniline

試薬・触媒・溶媒 2

HCID 935Nickel触媒HCID 702Ethanol溶媒

実験手順

In 30 volume parts of ethanol is dissolved 1.87 parts of N1 -methyl-N4 -(2-nitrobenzyl)piperazine, followed by the addition of 3.0 parts of Raney nickel. Then, 3.0 parts of hydrazine hydrate is further added to the mixture and the entire mixture is kept at room temperature for 2 hours. Following this reaction, the Raney nickel is filtered off and the solvent is distilled off under reduced pressure. The residual oily substance is recrystallized from aqueous methanol. The procedure gives pale yellow crystals melting at 78° to 79° C.

後処理

  1. customthis reaction
  2. filtrationthe Raney nickel is filtered off
  3. distillationthe solvent is distilled off under reduced pressure
  4. customThe residual oily substance is recrystallized from aqueous methanol

出典と根拠

ORDレコード
ord-95c8fb53c13d473a95aa0562f28fc929
出典データセット
uspto-grants-1979_05
特許番号
US04153794

関連ノート

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