Methanol → (3-Methoxypyridin-2-yl)methanol
反応式
[BH4-].[Na+].[CH3:3][O:4][C:5]1[C:6]([C:11](OC)=[O:12])=[N:7][CH:8]=[CH:9][CH:10]=1.CO>C(O)C>[OH:12][CH2:11][C:6]1[C:5]([O:4][CH3:3])=[CH:10][CH:9]=[CH:8][N:7]=1参加物
5
実験手順
Sodium borohydride (6.3 g) was added slowly over 75 minutes to a solution of 3-methoxy-2-methoxycarbonylpyridine (9.2 g) in ethanol. Methanol (100 ml) was then added and after the initial vigorous reaction had subsided, further sodium borohydride (8.3 g) was added over a further 3 hours, and the mixture was left to stand overnight. The solvent was evaporated, the residue dissolved in water and extracted with chloroform and the chloroform solution dried. Evaporation, and crystallisation from ether gave 2-hydroxymethyl-3-methoxypyridine (4.4 g) m.p. 72.5°-73.5°.
後処理
- customafter the initial vigorous reaction
- waitthe mixture was left
- customThe solvent was evaporated
- dissolutionthe residue dissolved in water
- extractionextracted with chloroform
- dry with materialthe chloroform solution dried
- customEvaporation, and crystallisation from ether
出典と根拠
- ORDレコード
- ord-72680b78a511439cb77fa07e56c442ac
- 出典データセット
- uspto-grants-1979_05
- 特許番号
- US04154838
反応ノート
読み込み中…