Ethanol → 1-(2,6-Dichlorobenzylideneamino)-3-(2-thenyl)guanidine

HRID 262768

反応式

HRID 262768 の反応式
I.[Cl:2][C:3]1[CH:15]=[CH:14][CH:13]=[C:12]([Cl:16])[C:4]=1[CH:5]=[N:6][NH:7][C:8](=[NH:11])SC.[NH2:17][CH2:18][C:19]1[S:20][CH:21]=[CH:22][CH:23]=1.C(O)C>O.[OH-].[Na+]>[Cl:2][C:3]1[CH:15]=[CH:14][CH:13]=[C:12]([Cl:16])[C:4]=1[CH:5]=[N:6][NH:7][C:8]([NH:17][CH2:18][C:19]1[S:20][CH:21]=[CH:22][CH:23]=1)=[NH:11]

参加物

6

反応物 3

HCID 702EthanolHCID 34005(2-Thienylmethyl)amineHCID 178504060Methyl 3-(2,6-dichlorobenzylidene)thiocarbazimidate hydroiodide

生成物 1

HCID 1785121161-(2,6-Dichlorobenzylideneamino)-3-(2-thenyl)guanidine

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 14798Sodium Hydroxide溶媒

実験手順

A solution of 5.85 g. of methyl 3-(2,6-dichlorobenzylidene)thiocarbazimidate hydriodide and 3.39 g. of 2-(aminomethyl)thiophene in 25 ml. of absolute ethanol is heated under reflux for 16 hours, diluted with water and excess 10N sodium hydroxide is added. After standing, crystallization occurs, and filtration gives 3.50 g. of nearly colorless crystals. Recrystallization from aqueous ethanol gives the desired product as colorless crystals, m.p. 135°-137° C.

後処理

  1. temperatureunder reflux for 16 hours
  2. additionis added
  3. customcrystallization
  4. filtrationfiltration
  5. customgives 3.50 g
  6. customRecrystallization from aqueous ethanol

出典と根拠

ORDレコード
ord-99cc69d1626a41b6ac9ae6c77d9a89d0
出典データセット
uspto-grants-1979_05
特許番号
US04154947

関連ノート

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