p-Toluenesulfonic acid → 3-(3-Chloro-4-isopropyl-phenyl)-5-methyl-tetrahydro-1,3,5-oxadiazin-4-one

HRID 262930

反応式

HRID 262930 の反応式
[Cl:1][C:2]1[CH:3]=[C:4]([NH:11][C:12]([N:14]([CH3:16])[CH3:15])=[O:13])[CH:5]=[CH:6][C:7]=1[CH:8]([CH3:10])[CH3:9].C1(C)C=CC(S(O)(=O)=O)=CC=1.[O:28]1CCOC[CH2:29]1>C1C=CC=CC=1>[Cl:1][C:2]1[CH:3]=[C:4]([N:11]2[C:12](=[O:13])[N:14]([CH3:15])[CH2:16][O:28][CH2:29]2)[CH:5]=[CH:6][C:7]=1[CH:8]([CH3:9])[CH3:10]

参加物

6

反応物 4

HCID 6101p-Toluenesulfonic acidHCID 312751,4-DioxaneHCID 182166Urea, 3-(3-chloro-p-cumenyl)-1,1-dimethyl-HCID 178486302HCID 178486302、化合物

生成物 1

HCID 213170623-(3-Chloro-4-isopropyl-phenyl)-5-methyl-tetrahydro-1,3,5-oxadiazin-4-one

試薬・触媒・溶媒 1

HCID 241Benzene溶媒

実験手順

N-(3-Chloro-4-isopropyl-phenyl)-N',N'-dimethylurea (22.65 g.=0.1 mol) is dissolved in a solvent mixture comprising dioxane (50 cc.) and benzene (80 cc.). After adding p-toluenesulphonic acid (1 g.) and polyoxymethylene (8.1 g.), the solution is heated under reflux for 1 hour in a flask equipped with a Dean and Stark apparatus with a reflux condenser. 3.7 cc. of aqueous phase are collected.

後処理

  1. temperaturethe solution is heated
  2. temperatureunder reflux for 1 hour in a flask
  3. customequipped with a Dean and Stark apparatus with a reflux condenser
  4. customof aqueous phase are collected

出典と根拠

ORDレコード
ord-3baba906511849bd9ab44f03dbbc55e8
出典データセット
uspto-grants-1979_05
特許番号
US04155747

関連ノート

読み込み中…