Sodium Iodide → 1-iodo-7-(bicyclo[3.2.1]oct-2-yl)-1-E-hepten-3-one

HRID 26307ノート

反応式

HRID 26307 の反応式
Cl/[CH:2]=[CH:3]/[C:4](=[O:17])[CH2:5][CH2:6][CH2:7][CH2:8][CH:9]1[CH2:15][CH2:14][CH:13]2[CH2:16][CH:10]1[CH2:11][CH2:12]2.[I-:18].[Na+]>CC(C)=O>[I:18]/[CH:2]=[CH:3]/[C:4](=[O:17])[CH2:5][CH2:6][CH2:7][CH2:8][CH:9]1[CH2:15][CH2:14][CH:13]2[CH2:16][CH:10]1[CH2:11][CH2:12]2

参加物

4

反応物 2

HCID 5238Sodium IodideHCID 21325429HCID 21325429、化合物

生成物 1

HCID 213254401-iodo-7-(bicyclo[3.2.1]oct-2-yl)-1-E-hepten-3-one収率 88%

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

実験手順

A solution of 3.2 g (13 mmol) of 1-chloro-7-(bicyclo-[3.2.1]oct-2-yl)-1E-hepten-3-one and 7.5 g (50 mmol) of sodium iodide in 25 ml of dry acetone (distilled from potassium carbonate) was refluxed for 18 hr under nitrogen. The solvent was removed in vacuo, and the residue was taken up in 50 ml of water and then extracted three times with 30 ml portions of ether. The combined ether extracts were washed with aqueous sodium thiosulfate, dried (MgSO4) and evaporated in vacuo to yield 3.8 g (88%) of 1-iodo-7-(bicyclo[3.2.1]oct-2-yl)-1-E-hepten-3-one.

後処理

  1. customThe solvent was removed in vacuo
  2. extractionextracted three times with 30 ml portions of ether
  3. washThe combined ether extracts were washed with aqueous sodium thiosulfate
  4. dry with materialdried (MgSO4)
  5. customevaporated in vacuo

出典と根拠

ORDレコード
ord-65e3ecf792784c20b62b29e6c0afa920
出典データセット
uspto-grants-1979_04
特許番号
US04149017

反応ノート

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