Dimethylformamide → 2-Sulfo-2-(1-pyrryl)acetyl chloride
反応式
[S:1]([CH:5]([N:9]1[CH:13]=[CH:12][CH:11]=[CH:10]1)[C:6](O)=[O:7])([OH:4])(=[O:3])=[O:2].S(Cl)([Cl:16])=O.CN(C)C=O.CCCCCC>CCOCC>[S:1]([CH:5]([N:9]1[CH:13]=[CH:12][CH:11]=[CH:10]1)[C:6]([Cl:16])=[O:7])([OH:4])(=[O:3])=[O:2]参加物
6
反応条件
- 温度
- 40 °C
実験手順
2-Sulfo-2-(1-pyrryl)acetic acid is treated with thionyl chloride in ether at room temperature according to the general procedure in J. Med. Chem., 15, 1105 (1972) until the evolution of gas stops. Dimethylformamide is added, the solution is warmed to about 40° C. for 1 hour. Then ether is added, followed by hexane and the solution cooled to about -25° C. 2-Sulfo-2-(1-pyrryl)acetyl chloride is isolated from the solvent by decantation.
後処理
- temperaturethe solution cooled to about -25° C
出典と根拠
- ORDレコード
- ord-e1561fb8a76442beaa3c4d1d9f935f62
- 出典データセット
- uspto-grants-1979_04
- 特許番号
- US04148998
反応ノート
読み込み中…