tert-Butyl isocyanate → HCID 21316843、化合物

HRID 263267

反応式

HRID 263267 の反応式
[CH3:1][C:2]([NH2:6])([CH3:5])[C:3]#[N:4].[C:7]([N:11]=[C:12]=[O:13])([CH3:10])([CH3:9])[CH3:8]>>[C:3]([C:2]([NH:6][C:12]([NH:11][C:7]([CH3:10])([CH3:9])[CH3:8])=[O:13])([CH3:5])[CH3:1])#[N:4]

参加物

3

反応物 2

HCID 62412tert-Butyl isocyanateHCID 880222-Amino-2-methylpropionitrile

生成物 1

HCID 21316843HCID 21316843、化合物

実験手順

In a nitrogen atmosphere, 24.8 g. (0.3 mole) 2-methyl-2-aminopropionitrile and 30.7 g. (0.3 mole) t-butyl isocyanate, 97%, are combined and stirred for 5 minutes. At the end of this period, the mixture is filtered and 1 ml. of pyridine is added to the filtrate. This mixture is heated in an oil bath for one and one-half hours, keeping the temperature of the bath below 70°. The solid is recrystallized from methanol:water, 60:40, to give N-(1-cyano-1-methylethyl)-N'-(1,1-dimethylethyl)urea, m.p. 204°-5°; Anal. Calcd. for C9H17N3O; C: 58.99, H: 9.35, N: 22.93; Found: C: 59.21, H: 9.26, N: 22.59.

後処理

  1. filtrationAt the end of this period, the mixture is filtered
  2. additionof pyridine is added to the filtrate
  3. temperatureThis mixture is heated in an oil bath for one and one-half hours
  4. customthe temperature of the bath below 70°
  5. customThe solid is recrystallized from methanol

出典と根拠

ORDレコード
ord-23879c3033134182b765916ff9ed125b
出典データセット
uspto-grants-1979_05
特許番号
US04156738

関連ノート

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