HCID 22218187、化合物 → 3-methanesulfonyl-2-methylpropanoic acid

HRID 263474ノート

反応式

HRID 263474 の反応式
[CH3:1][S:2]([CH2:5][C:6](=[CH2:10])[C:7]([OH:9])=[O:8])(=[O:4])=[O:3]>CO.[Pd]>[CH3:10][CH:6]([CH2:5][S:2]([CH3:1])(=[O:4])=[O:3])[C:7]([OH:9])=[O:8]

参加物

4

反応物 1

HCID 22218187HCID 22218187、化合物

生成物 1

HCID 221423443-methanesulfonyl-2-methylpropanoic acid収率 96.3%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

A solution of 2-(methylsulfonylmethyl) acrylic acid (700 mg, 4.26 mmol) in 20 mL of methanol was charged into a Fisher-Porter bottle along with 10% palladium on carbon catalyst under a nitrogen atmosphere. The reaction vessel was sealed and flushed five times with nitrogen and then five times with hydrogen. The pressure was maintained at 50 psig for 16 hours and then the hydrogen was replaced with nitrogen and the solution filtered through a pad of celite to remove the catalyst and the filterate concentrated in vacuo to give 682 mg 96% of 2-(R,S)-methyl-3-methylsulfonyl propionic acid; formula: ##STR79##

後処理

  1. customThe reaction vessel was sealed
  2. customflushed five times with nitrogen
  3. temperatureThe pressure was maintained at 50 psig for 16 hours
  4. filtrationthe solution filtered through a pad of celite
  5. customto remove the catalyst
  6. concentrationthe filterate concentrated in vacuo

出典と根拠

ORDレコード
ord-5b3f4ebc12e547539ca51f1c83076f3c
出典データセット
uspto-grants-1997_07
特許番号
US05643924

反応ノート

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