Nitric Acid → 4-Chloro-2-methyl-5-nitroaniline

HRID 263822

反応式

HRID 263822 の反応式
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([Cl:8])=[CH:4][C:3]=1[CH3:9].[N+:10]([O-])([OH:12])=[O:11]>S(=O)(=O)(O)O>[NH2:1][C:2]1[CH:7]=[C:6]([N+:10]([O-:12])=[O:11])[C:5]([Cl:8])=[CH:4][C:3]=1[CH3:9]

参加物

4

反応物 2

HCID 944Nitric AcidHCID 72514-Chloro-2-toluidine

生成物 1

HCID 2929654-Chloro-2-methyl-5-nitroaniline

試薬・触媒・溶媒 1

HCID 1118Sulfuric Acid溶媒2 回

実験手順

7 g (20 mmol) of 2-amino-5-chlorotoluene were dissolved in 10 ml of sulfuric acid at 10° C. to form a reactant solution. 2.05 ml fuming nitric acid were dissolved in 10 ml concentrated sulfuric acid and the resultant acidic solution was added slowly dropwise to the reactant solution. The reactant solution was then stirred for 3 to 4 hours at room temperature and subsequently added to ice. The yellow product crystals were filtered with suction and recrystallized from methanol. 6.4 g (70% of the theoretical yield) of 2-amino-5-chloro-4-nitrotoluene, which melted at 115° C., were obtained.

後処理

  1. customto form a reactant solution
  2. additionthe resultant acidic solution was added slowly dropwise to the reactant solution
  3. additionsubsequently added to ice
  4. filtrationThe yellow product crystals were filtered with suction
  5. customrecrystallized from methanol

出典と根拠

ORDレコード
ord-9b5a8c1124274c03b660e1b2f36ca95e
出典データセット
uspto-grants-1997_07
特許番号
US05645610

関連ノート

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