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4-Chlorobenzaldehyde → Methyl 5-acetyl-2,6-dimethyl-4-(4-chlorophenyl)-1,4-dihydropyridine-3-carboxylate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-Chlorobenzaldehyde | HCID 7726 | — |
| 反応物 | Methyl acetoacetate | HCID 7757 | — |
| 反応物 | 4-Amino-3-penten-2-one | HCID 136873 | — |
| 溶媒 | Isopropanol | HCID 3776 | — |
| 生成物 | Methyl 5-acetyl-2,6-dimethyl-4-(4-chlorophenyl)-1,4-dihydropyridine-3-carboxylate | HCID 15337221 | — |
反応手順
5.64 g (40 mmol) of 4-chlorobenzaldehyde, 4.0 g (40 mmol) of 4-aminopent-3-en-2-one and 4.6 g (40 mmol) of methyl acetoacetate are heated to reflux for 12 h in 100 ml of isopropanol. The reaction mixture is allowed to cool and is concentrated. 1.85 g of the title compound crystallize from Et2O.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05646166 |
| 出典データセット | uspto-grants-1997_07 |
| ORD ID | ord-28c0316e636846f197225b123a7a9827 |
| 出典メモ | uspto-grants-1997_07 |