Thionyl Chloride → HCID 10467905、化合物
反応式
[Cl:1][CH2:2][CH2:3][CH2:4][O:5][C:6]1[CH:14]=[CH:13][C:9]([C:10](O)=[O:11])=[CH:8][C:7]=1[O:15][CH3:16].S(Cl)([Cl:19])=O>ClCCl>[Cl:1][CH2:2][CH2:3][CH2:4][O:5][C:6]1[CH:14]=[CH:13][C:9]([C:10]([Cl:19])=[O:11])=[CH:8][C:7]=1[O:15][CH3:16]参加物
4
実験手順
To a mixture of 4-(3-chloropropoxy)-3-methoxybenzoic acid (2.4 g, 10 mmol) in dichloromethane (5 ml) was added thionyl chloride (0.9 ml, 12 mmol) dissolved in dichloromethane (5 ml). The reaction was stirred and refluxed for 1 hour, and then the dichloromethane was removed in vacuo to leave a dark oil. The oil was triturated with hexane and the solid that formed while scratching with a glass rod was collected to afford 1.6 g of 4-(3-chloropropoxy)-3-methoxybenzoyl chloride, m.p.=60°-63° C.
後処理
- temperaturerefluxed for 1 hour
- customthe dichloromethane was removed in vacuo
- customto leave a dark oil
- customThe oil was triturated with hexane
- customthe solid that formed
- customwas collected
出典と根拠
- ORDレコード
- ord-024a20cb42544328b9198b7257eadfdd
- 出典データセット
- uspto-grants-1997_07
- 特許番号
- US05646161
反応ノート
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