4-Methoxybenzenesulfonyl chloride → N-benzyl-4-methoxybenzenesulfonamide

HRID 264311

反応式

HRID 264311 の反応式
[CH2:1]([NH2:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:9][O:10][C:11]1[CH:16]=[CH:15][C:14]([S:17](Cl)(=[O:19])=[O:18])=[CH:13][CH:12]=1>C(Cl)(Cl)Cl>[CH3:9][O:10][C:11]1[CH:12]=[CH:13][C:14]([S:17]([NH:8][CH2:1][C:2]2[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=2)(=[O:19])=[O:18])=[CH:15][CH:16]=1

参加物

4

反応物 2

HCID 74014-Methoxybenzenesulfonyl chlorideHCID 7504Benzylamine

生成物 1

HCID 741351N-benzyl-4-methoxybenzenesulfonamide

試薬・触媒・溶媒 1

HCID 6212Chloroform溶媒

反応条件

温度
0 °C

実験手順

Benzylamine (16.0 mL, 145.2 mmol) is dissolved in chloroform (110 mL), and the solution is cooled to 0° C. To this solution is added 4-methoxybenzenesulfonyl chloride (10.0 g, 48.4 mmol). The reaction is stirred at room temperature for 1 hour, and then refluxed for 1 hour. After cooling back to room temperature, the reaction is washed three times with 4N hydrochloric acid (200 mL), twice with water (100 mL), once with brine (50 mL), then dried (Na2SO4), and the solvent is evaporated to give N-[4-methoxybenzenesulfonyl]-benzylamine.

後処理

  1. temperaturerefluxed for 1 hour
  2. temperatureAfter cooling back to room temperature
  3. washthe reaction is washed three times with 4N hydrochloric acid (200 mL)
  4. dry with materialtwice with water (100 mL), once with brine (50 mL), then dried (Na2SO4)
  5. customthe solvent is evaporated

出典と根拠

ORDレコード
ord-480680a942d14e20afb3ab5e47cdfdb3
出典データセット
uspto-grants-1997_07
特許番号
US05646167

関連ノート

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