N-Benzyloxy-2(R)-[[4-methoxybenzenesulfonyl](3-picolyl)amino]-3-methylbutanamide → Cgs-27023

HRID 264332

反応式

HRID 264332 の反応式
C([O:8][NH:9][C:10](=[O:34])[C@H:11]([N:15]([S:23]([C:26]1[CH:31]=[CH:30][C:29]([O:32][CH3:33])=[CH:28][CH:27]=1)(=[O:25])=[O:24])[CH2:16][C:17]1[CH:18]=[N:19][CH:20]=[CH:21][CH:22]=1)[CH:12]([CH3:14])[CH3:13])C1C=CC=CC=1.[H][H]>[Pd]>[OH:8][NH:9][C:10](=[O:34])[C@H:11]([N:15]([S:23]([C:26]1[CH:31]=[CH:30][C:29]([O:32][CH3:33])=[CH:28][CH:27]=1)(=[O:25])=[O:24])[CH2:16][C:17]1[CH:18]=[N:19][CH:20]=[CH:21][CH:22]=1)[CH:12]([CH3:14])[CH3:13]

参加物

4

反応物 2

HCID 22856293N-Benzyloxy-2(R)-[[4-methoxybenzenesulfonyl](3-picolyl)amino]-3-methylbutanamideHCID 178418361HCID 178418361、化合物

生成物 1

HCID 446504Cgs-27023

試薬・触媒・溶媒 1

HCID 23938Palladium触媒

実験手順

N-Benzyloxy-2(R)-[[4-methoxybenzenesulfonyl](3-picolyl)amino]-3-methylbutanamide (see example 29a) is reacted with hydrogen in the presence of 10% palladium on charcoal catalyst at room temperature and atmospheric pressure to yield N-hydroxy-2(R)-[[4-methoxybenzenesulfonyl](3-picolyl)amino]-3-methylbutanamide. After conversion to the hydrochloride salt, a white solid is obtained, m.p. 169°-170° C. (dec).

出典と根拠

ORDレコード
ord-09a3d121d10d4bbe92231a4692af8abc
出典データセット
uspto-grants-1997_07
特許番号
US05646167

関連ノート

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