Water → 2-(p-Isobutylphenyl)propionic acid cyclopropylmethyl ester

HRID 26452

反応式

HRID 26452 の反応式
[Na].[CH3:2][O:3][C:4](=[O:17])[CH:5]([C:7]1[CH:12]=[CH:11][C:10]([CH2:13][CH:14]([CH3:16])[CH3:15])=[CH:9][CH:8]=1)[CH3:6].O.[CH:19]1(CO)[CH2:21][CH2:20]1>>[CH:19]1([CH2:2][O:3][C:4](=[O:17])[CH:5]([C:7]2[CH:8]=[CH:9][C:10]([CH2:13][CH:14]([CH3:16])[CH3:15])=[CH:11][CH:12]=2)[CH3:6])[CH2:21][CH2:20]1

参加物

5

反応物 4

HCID 962WaterHCID 75644CyclopropanemethanolHCID 109101Ibuprofen methyl esterHCID 5360545Sodium

生成物 1

HCID 541003282-(p-Isobutylphenyl)propionic acid cyclopropylmethyl ester

反応条件

温度
50 °C

実験手順

A mixture of 0.05 g of sodium in 20 ml of cyclopropylmethyl alcohol was heated at 50° C. for 5 hours. To the mixture was added 2.2 g of 2-(p-isobutylphenyl)propionic acid methyl ester and the whole was refluxed for 10 hours. After the reaction was completed, the solvent was removed by distillation under reduced pressure to leave a residue, to which was added water. The resulting mixture was extracted with ether, and the extract was washed sufficiently with water and then dehydrated. The ether was removed by distillation to leave a residual oily product. This product was then distilled under reduced pressure to yield 1.38 g of 2-(p-isobutylphenyl)propionic acid cyclopropylmethyl ester as a colorless oil, boiling at 109°-111° C./1 mmHg. Analysis-Calculated for C17H24O2 : C, 78.42; H, 9.29. Found: C, 78.19; H, 9.22.

後処理

  1. temperaturethe whole was refluxed for 10 hours
  2. customthe solvent was removed by distillation under reduced pressure
  3. customto leave a residue
  4. extractionThe resulting mixture was extracted with ether
  5. washthe extract was washed sufficiently with water
  6. customThe ether was removed by distillation
  7. customto leave a residual oily product
  8. distillationThis product was then distilled under reduced pressure

出典と根拠

ORDレコード
ord-52033678e3be4b61b382c19ce0ac7f52
出典データセット
uspto-grants-1979_04
特許番号
US04150137

関連ノート

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