Ammonia → 2-Aminoadenosine

HRID 264715

反応式

HRID 264715 の反応式
[NH3:1].O.[C@@H:3]1([N:12]2[C:22]3[N:21]=[C:19]([NH2:20])[NH:18][C:16](=O)[C:15]=3[N:14]=[CH:13]2)[O:11][C@H:8]([CH2:9][OH:10])[C@@H:6]([OH:7])[C@H:4]1[OH:5].Cl[Si](C)(C)C>O>[NH2:20][C:19]1[N:21]=[C:22]2[C:15]([N:14]=[CH:13][N:12]2[C@@H:3]2[O:11][C@H:8]([CH2:9][OH:10])[C@@H:6]([OH:7])[C@H:4]2[OH:5])=[C:16]([NH2:1])[N:18]=1

参加物

5

反応物 3

HCID 222Ammonia2 回HCID 6397ChlorotrimethylsilaneHCID 135705230Guanosine Hydrate

生成物 1

HCID 722002-Aminoadenosine

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

This variation of the procedures of Robins, et al. supra, eliminated the need to utilize liquid ammonia in the reaction mixture since the ammonia molecule is generated in situ from the silazane reagent and the water of hydration of the guanosine hydrate starting material. Further, the use of chlorotrimethylsilane was not necessary nor was it necessary to conduct the reaction under anhydrous conditions, do a preliminary evaporation, or open and re-seal the Parr bomb under a dry nitrogen atmosphere.

後処理

  1. customthe reaction under anhydrous conditions
  2. customa preliminary evaporation
  3. customopen and re-seal the Parr bomb under a dry nitrogen atmosphere

出典と根拠

ORDレコード
ord-494fc1639bc14d2596e0d0c070bd9931
出典データセット
uspto-grants-1997_07
特許番号
US05646265

関連ノート

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