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Succinic anhydride → 3-[4-(2-Fluorophenyl)benzoyl]propanoic acid

HRID 264774
ノート
印刷プレビュー

反応式

HRID 264774 の反応式
[Cl-].[Cl-].[Cl-].[Al+3].[C:5]1(=[O:11])[O:10][C:8](=[O:9])[CH2:7][CH2:6]1.[F:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=1[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1>ClC(Cl)C.Cl>[F:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=1[C:19]1[CH:20]=[CH:21][C:22]([C:5]([CH2:6][CH2:7][C:8]([OH:10])=[O:9])=[O:11])=[CH:23][CH:24]=1
参加物実験手順後処理出典と根拠反応ノート

参加物

6

反応物 3

HCID 7922Succinic anhydrideHCID 675792-FluorobiphenylHCID 6451240Aluminum(III) Chloride

生成物 1

HCID 137582703-[4-(2-Fluorophenyl)benzoyl]propanoic acid収率 89%

試薬・触媒・溶媒 2

HCID 313Hydrochloric Acid溶媒HCID 63651,1-Dichloroethane溶媒

実験手順

Aluminum trichloride (6.2 g, 46.5 mmol) was suspended in 50 ml of dichloroethane, and 3.02 g (30.2 mmol) of succinic anhydride and 4.0 g (23.2 mmol) of 2-fluorobiphenyl were added thereto, followed by stirring the mixture at room temperature for 4 hours. The reaction solution was poured in hydrochloric acid containing ice, and extracted with chloroform. The organic layer was washed with water, and dried over anhydrous magnesium sulfate. After the solvent was distilled off under reduced pressure, the residue was recrystallized from chloroform to obtain 5.6 g of the above-mentioned compound (yield 89%).

後処理

  1. additioncontaining ice
  2. extractionextracted with chloroform
  3. washThe organic layer was washed with water
  4. dry with materialdried over anhydrous magnesium sulfate
  5. distillationAfter the solvent was distilled off under reduced pressure
  6. customthe residue was recrystallized from chloroform

出典と根拠

ORDレコード
ord-28286910cf354cf7a57fbfcb95e41098
出典データセット
uspto-grants-1997_07
DOI
10.6084/m9.figshare.5104873.v1
特許番号
US05646283

反応ノート

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