Methyl iodide → 2-Methoxyphenethyl alcohol

HRID 264915

反応式

HRID 264915 の反応式
[OH:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:8][CH2:9][OH:10].[C:11]([O-])([O-])=O.[Cs+].[Cs+].CI>CC(C)=O>[OH:10][CH2:9][CH2:8][C:3]1[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=1[O:1][CH3:11]

参加物

5

反応物 3

HCID 6328Methyl iodideHCID 10796Cesium carbonateHCID 822002-(2-Hydroxyethyl)phenol

生成物 1

HCID 819092-Methoxyphenethyl alcohol

試薬・触媒・溶媒 1

HCID 180Acetone溶媒2 回

実験手順

To a solution of 10 g of 2-(2-hydroxyphenyl)-ethanol in 200 ml of acetone there are added 35.3 g of Cs2CO3 and then a solution of 6.5 ml of methyl iodide in 40 ml of acetone. The reaction mixture is stirred for 50 minutes at room temperature, is filtered and is concentrated by evaporation. The residue is partitioned between diethyl ether and water. The organic phases are combined, dried over magnesium sulfate and concentrated by evaporation, and the residue is purified by means of FC (dichloromethane/diethyl ether=97:3), yielding the title compound: Rf (dichloromethane/diethyl ether=97:3)=0.34; HPLC Rt =9.31 minutes.

後処理

  1. filtrationis filtered
  2. concentrationis concentrated by evaporation
  3. customThe residue is partitioned between diethyl ether and water
  4. dry with materialdried over magnesium sulfate
  5. concentrationconcentrated by evaporation
  6. customthe residue is purified by means of FC (dichloromethane/diethyl ether=97:3)

出典と根拠

ORDレコード
ord-1df21698c46c4cba86e23de38fb962c5
出典データセット
uspto-grants-1997_07
特許番号
US05646143

関連ノート

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