Sodium Hydroxide → 2-[N-(3-Carboxypropyl)-isobutyramido]-4-methyloxazole

HRID 26493ノート

反応式

HRID 26493 の反応式
[C:1]([CH2:6][CH2:7][CH2:8][N:9]([C:15]1[O:16][CH:17]=[C:18]([CH3:20])[N:19]=1)[C:10](=[O:14])[CH:11]([CH3:13])[CH3:12])([O:3]CC)=[O:2].[OH-].[Na+]>C(O)C>[C:1]([CH2:6][CH2:7][CH2:8][N:9]([C:15]1[O:16][CH:17]=[C:18]([CH3:20])[N:19]=1)[C:10](=[O:14])[CH:11]([CH3:13])[CH3:12])([OH:3])=[O:2]

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 213236572[N-(3-carbethoxypropyl)-isobutyramido]-4-methyloxazole

生成物 1

HCID 213236712-[N-(3-Carboxypropyl)-isobutyramido]-4-methyloxazole収率 57.3%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

A solution of 2[N-(3-carbethoxypropyl)-isobutyramido]-4-methyloxazole (9.9 g., 0.035 mol.) prepared in a manner similar to that described in Example 44 was dissolved in ethanol (100 ml.) and N NaOH solution (35 ml.) and the solution was stirred for 20 hours at ambient temperature. The solution was evaporated and the residue was dissolved in water, washed with ether, acidified and extracted with ether. The extract was dried and evaporated and the residue was recrystallised from benzene-- petrol to give the product 5.1 g., m.p. 81°- 82° C.

後処理

  1. customThe solution was evaporated
  2. dissolutionthe residue was dissolved in water
  3. washwashed with ether
  4. extractionextracted with ether
  5. customThe extract was dried
  6. customevaporated
  7. customthe residue was recrystallised from benzene-- petrol

出典と根拠

ORDレコード
ord-31d1524c6d344960a649fea493767c04
出典データセット
uspto-grants-1979_04
特許番号
US04150143

反応ノート

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