2-Methyl-3-phenylprop-2-enoic acid → alpha-Methylhydrocinnamic acid

HRID 264979

反応式

HRID 264979 の反応式
[CH3:1][C:2](=[CH:6][C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1)[C:3]([OH:5])=[O:4]>CO.[Pd]>[CH3:1][CH:2]([CH2:6][C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1)[C:3]([OH:5])=[O:4]

参加物

4

反応物 1

HCID 145412-Methyl-3-phenylprop-2-enoic acid

生成物 1

HCID 99862alpha-Methylhydrocinnamic acid

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒2 回

実験手順

A solution of α-methyl cinnamic acid (10.0 g., 61.7 mmol.) in dry methanol (250 ml.) was treated with 10% palladium on carbon and hydrogenated (balloon used) at room temperature for 16 hours. The reaction mixture was diluted with methanol (250 ml.), filtered through a Celite pad in a millipore unit, washing the pad well with methanol (2×100 ml.). The clear filtrate was evaporated to dryness to give 10.225 g. of title product as a thick syrup.

後処理

  1. filtrationfiltered through a Celite pad in a millipore unit
  2. washwashing the pad well with methanol (2×100 ml.)
  3. customThe clear filtrate was evaporated to dryness
  4. customto give 10.225 g

出典と根拠

ORDレコード
ord-32282b74b54342d1868141ab94bdda01
出典データセット
uspto-grants-1997_07
特許番号
US05646276

関連ノート

読み込み中…