Sodium Hydroxide → HCID 178440149、化合物

反応式

[OH:1][CH:2]([C:6]1[N:7]=[C:8]([CH2:31][CH2:32][CH3:33])[N:9]([CH2:13][C:14]2[CH:19]=[CH:18][C:17]([C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=3[C:26]3[NH:30][N:29]=[N:28][N:27]=3)=[CH:16][CH:15]=2)[C:10]=1[C:11]#[N:12])[CH:3]([CH3:5])[CH3:4].[OH-:34].[Na+]>>[OH:1][CH:2]([C:6]1[N:7]=[C:8]([CH2:31][CH2:32][CH3:33])[N:9]([CH2:13][C:14]2[CH:19]=[CH:18][C:17]([C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=3[C:26]3[NH:30][N:29]=[N:28][N:27]=3)=[CH:16][CH:15]=2)[C:10]=1[C:11]([NH2:12])=[O:34])[CH:3]([CH3:5])[CH3:4]

参加物

反応物 2

HCID 14798Sodium Hydroxide

HCID 178440147HCID 178440147、化合物

生成物 1

HCID 178440149HCID 178440149、化合物

実験手順

Following a procedure similar to that described in Example 74(d), but using 0.90 g of 4-(1-hydroxy-2-methylpropyl)-2-propyl-1-{4-[2-(tetrazol-5-yl)-phenyl]phenyl}methylimidazole-5-carbonitrile [prepared as described in step (c) above] in a 1N aqueous solution of sodium hydroxide, 0.64 g of the title compound was obtained as a powder, melting at 153°-157° C.

出典と根拠

ORDレコード: ord-c6d23b4b2d49448b9ef40e0d45a94b69
出典データセット: uspto-grants-1997_07
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US05646171

反応ノート

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