Sodium Hydroxide → 4-(1-Hydroxy-1-methylethyl)-2-(1-methoxyethyl)-1-{4-[2-(tetrazol-5-yl)phenyl]phenyl}methylimidazole-5-carboxylic acid

HRID 265141

反応式

HRID 265141 の反応式
[OH:1][C:2]([C:5]1[N:6]=[C:7]([CH:32]([O:34][CH3:35])[CH3:33])[N:8]([CH2:14][C:15]2[CH:20]=[CH:19][C:18]([C:21]3[CH:26]=[CH:25][CH:24]=[CH:23][C:22]=3[C:27]3[NH:31][N:30]=[N:29][N:28]=3)=[CH:17][CH:16]=2)[C:9]=1[C:10]([O:12]C)=[O:11])([CH3:4])[CH3:3].[OH-].[Na+]>>[OH:1][C:2]([C:5]1[N:6]=[C:7]([CH:32]([O:34][CH3:35])[CH3:33])[N:8]([CH2:14][C:15]2[CH:20]=[CH:19][C:18]([C:21]3[CH:26]=[CH:25][CH:24]=[CH:23][C:22]=3[C:27]3[NH:31][N:30]=[N:29][N:28]=3)=[CH:17][CH:16]=2)[C:9]=1[C:10]([OH:12])=[O:11])([CH3:3])[CH3:4]

参加物

3

反応物 2

HCID 14798Sodium HydroxideHCID 178497993Methyl 4-(1-hydroxy-1-methylethyl)-2-(1-methoxyethyl)-1-{4-[2-(tetrazol-5-yl)phenyl]phenyl}methylimidazole-5-carboxylate

生成物 1

HCID 1784948214-(1-Hydroxy-1-methylethyl)-2-(1-methoxyethyl)-1-{4-[2-(tetrazol-5-yl)phenyl]phenyl}methylimidazole-5-carboxylic acid

実験手順

A solution of 331 m9 of methyl 4-(1-hydroxy-1-methylethyl)-2-(1-methoxyethyl)-1-{4-[2-(tetrazol-5-yl)phenyl]phenyl}methylimidazole-5-carboxylate [prepared as described in Example 94(b)] in 3 ml of a 1N aqueous solution of sodium hydroxide was stirred at room temperature for 2.5 hours. At the end of this time, insoluble matter was filtered off and 3 ml of 1N aqueous hydrochloric acid was added to the filtrate. The amorphous powder which precipitated was collected by filtration, to give 209 mg of the title compound, melting at 174°-185° C. (with softening).

後処理

  1. filtrationAt the end of this time, insoluble matter was filtered off
  2. addition3 ml of 1N aqueous hydrochloric acid was added to the filtrate
  3. customThe amorphous powder which precipitated
  4. filtrationwas collected by filtration

出典と根拠

ORDレコード
ord-c65f3f1f460a40cd9239562600be85c1
出典データセット
uspto-grants-1997_07
特許番号
US05646171

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