Hydrochloric Acid → N-(2quinolinylcarbonyl)-L-isoasparagine

HRID 265268

反応式

HRID 265268 の反応式
[NH2:1][C@H:2]([C:7](=[O:9])[NH2:8])[CH2:3][C:4]([OH:6])=[O:5].O.C(=O)(O)[O-].[C:15](O)(=[O:26])[C:16]1[CH:25]=[CH:24][C:23]2[C:18](=[CH:19][CH:20]=[CH:21][CH:22]=2)[N:17]=1.Cl>COCCOC>[N:17]1[C:18]2[C:23](=[CH:22][CH:21]=[CH:20][CH:19]=2)[CH:24]=[CH:25][C:16]=1[C:15]([NH:1][C@H:2]([C:7](=[O:9])[NH2:8])[CH2:3][C:4]([OH:6])=[O:5])=[O:26]

参加物

7

反応物 5

HCID 313Hydrochloric AcidHCID 769Bicarbonate IonHCID 962WaterHCID 7124Quinaldic AcidHCID 7015702Isoasparagine

生成物 1

HCID 59936550N-(2quinolinylcarbonyl)-L-isoasparagine収率 70%

試薬・触媒・溶媒 1

HCID 80711,2-Dimethoxyethane溶媒

実験手順

To a solution of 0.50 g (3.78 mmol) of L-isoasparagine in 5.0 mL H2O containing ~45 mg (1.5 eq) of solid bicarbonate. To this was added a suspension of 1.02 g (3.78 mmol) quinaldic acid, N-hydroxysuccinamide ester in ethylene glycol dimethylether, and the suspension was solubilized by the addition of 10 mL of dimethyfformamide. After 3 hours the solution was acidified by the addition of 5% HCl (aqueous) and the product was filtered and washed with water, dried under vacuum to yield 750 mg (70% yield) of N-(2-quinolinylcarbonyl)-L-isoasparagine.

後処理

  1. additionTo this was added
  2. additionthe suspension was solubilized by the addition of 10 mL of dimethyfformamide
  3. filtrationthe product was filtered
  4. washwashed with water
  5. customdried under vacuum

出典と根拠

ORDレコード
ord-ce810b99662841ceb2a3a0a35cbead99
出典データセット
uspto-grants-1997_07
特許番号
US05648364

関連ノート

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