Methanol → Ethyl 3-amino-4-cyclohexylphenylglyoxylate

HRID 26548

反応式

HRID 26548 の反応式
[N+:1]([C:4]1[CH:5]=[C:6]([C:16](=[O:22])[C:17]([O:19][CH2:20][CH3:21])=[O:18])[CH:7]=[CH:8][C:9]=1[CH:10]1[CH2:15][CH2:14][CH2:13][CH2:12][CH2:11]1)([O-])=O.CO.[H][H]>[Pd]>[NH2:1][C:4]1[CH:5]=[C:6]([C:16](=[O:22])[C:17]([O:19][CH2:20][CH3:21])=[O:18])[CH:7]=[CH:8][C:9]=1[CH:10]1[CH2:15][CH2:14][CH2:13][CH2:12][CH2:11]1

参加物

5

反応物 3

HCID 887MethanolHCID 20515200Ethyl 3-nitro-4-cyclohexylphenylglyoxylateHCID 178418361HCID 178418361、化合物2 回

生成物 1

HCID 20515218Ethyl 3-amino-4-cyclohexylphenylglyoxylate

試薬・触媒・溶媒 1

HCID 23938Palladium触媒

実験手順

A mixture of 15.3 g. (0.05 moles) of ethyl 3-nitro-4-cyclohexylphenylglyoxylate in 100 ml. methanol containing 0.05 mole citric acid and 1.5 g. of 5% palladium-on-carbon is shaken with hydrogen at 3 atm. pressure and 27° C. until 3 moles of hydrogen are absorbed. The mixture is filtered, washed with methanol and the filtrate concentrated in vacuo to obtain ethyl 3-amino-4-cyclohexylphenylglyoxylate, isolated as the citrate salt.

後処理

  1. additionA mixture of 15.3 g
  2. customare absorbed
  3. filtrationThe mixture is filtered
  4. washwashed with methanol
  5. concentrationthe filtrate concentrated in vacuo

出典と根拠

ORDレコード
ord-48b86e3e9c88454faa5e059d3c0e3355
出典データセット
uspto-grants-1979_04
特許番号
US04150148

関連ノート

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