Metaperiodic acid → 3-Chloro-4-cyclohexylbenzaldehyde
反応式
[Cl:1][C:2]1[CH:3]=[C:4]([CH:14]([OH:17])CO)[CH:5]=[CH:6][C:7]=1[CH:8]1[CH2:13][CH2:12][CH2:11][CH2:10][CH2:9]1.I(O)(=O)(=O)=O>O1CCCC1.CCOCC>[Cl:1][C:2]1[CH:3]=[C:4]([CH:5]=[CH:6][C:7]=1[CH:8]1[CH2:9][CH2:10][CH2:11][CH2:12][CH2:13]1)[CH:14]=[O:17]参加物
5
実験手順
To 115 g. of 1-(3-chloro-4-cyclohexylphenyl)-1,2-ethanediol in tetrahydrofuran (800 ml.) is added a solution of periodic acid (102 g.) in ether (750 ml.). The reaction mixture is stirred under nitrogen overnight. The reaction mixture is filtered and the filtrate is washed with water (3×200 ml) and placed over sodium sulfate. Removal of solvent gives a liquid residue which is then distilled to give 3-chloro-4-cyclohexylbenzaldehyde.
後処理
- filtrationThe reaction mixture is filtered
- washthe filtrate is washed with water (3×200 ml)
- customRemoval of solvent
- customgives a liquid residue which
- distillationis then distilled
出典と根拠
- ORDレコード
- ord-a183d513e694444e977da4dfb50779fe
- 出典データセット
- uspto-grants-1979_04
- 特許番号
- US04150148
反応ノート
読み込み中…