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Lithium Hydroxide → 4-[3-(Pyridin-4-yl)propyloxy]benzoic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Lithium Hydroxide | HCID 3939 | — |
| 反応物 | Tetrahydrofuran | HCID 8028 | — |
| 反応物 | Methyl 4-[3-(4-pyridinyl)propoxy]benzoate | HCID 53832197 | — |
| 溶媒 | DCM MeOH AcOH | HCID 21877243 | — |
| 生成物 | 4-[3-(Pyridin-4-yl)propyloxy]benzoic acid | HCID 19034145 | — |
反応手順
A solution of 19-4 (3.2 g, 11.9 mmol), 1N LiOH (25 mL), and THF (50 mL) was stirred overnight at ambient temperature. After 20 h, the solution was washed with EtOAc and then acidified with 10% KHSO4 to give a suspension of white solid. The aqueous portion was extracted with CHCl3 and then the aqueous portion containing the solid was filtered. After drying the solid at 50° C. for 3 h, 19-5 was obtained. Rf 0.47 (silica, 10/1/1 CH2Cl2 /CH3OH/AcOH).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05648368 |
| 出典データセット | uspto-grants-1997_07 |
| ORD ID | ord-d4fc639ea6b44fd5b7b8b593e7e817de |
| 出典メモ | uspto-grants-1997_07 |