反应详情

A solution of 19-4 (3.2 g, 11.9 mmol), 1N LiOH (25 mL), and THF (50 mL) was stirred overnight at ambient temperature. After 20 h, the solution was washed with EtOAc and then acidified with 10% KHSO4 to give a suspension of white solid. The aqueous portion was extracted with CHCl3 and then the aqueous portion containing the solid was filtered. After drying the solid at 50° C. for 3 h, 19-5 was obtained. Rf 0.47 (silica, 10/1/1 CH2Cl2 /CH3OH/AcOH).

1. washthe solution was washed with EtOAc
2. customto give
3. additiona suspension of white solid
4. extractionThe aqueous portion was extracted with CHCl3
5. additionthe aqueous portion containing the solid
6. filtrationwas filtered
7. customAfter drying the solid at 50° C. for 3 h
8. custom19-5 was obtained