Hydrochloric Acid → 4-[2-(N-Benzylimidazol-4-yl)ethyloxy]benzoic acid

HRID 265896ノート

反応式

HRID 265896 の反応式
[CH2:1]([N:8]1[CH:12]=[C:11]([CH2:13][CH2:14][O:15][C:16]2[CH:25]=[CH:24][C:19]([C:20]([O:22]C)=[O:21])=[CH:18][CH:17]=2)[N:10]=[CH:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[OH-].[Na+].Cl>CO>[CH2:1]([N:8]1[CH:12]=[C:11]([CH2:13][CH2:14][O:15][C:16]2[CH:17]=[CH:18][C:19]([C:20]([OH:22])=[O:21])=[CH:24][CH:25]=2)[N:10]=[CH:9]1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 18928610Methyl 4-[2-(1-Benzylimidazol-4-yl)ethyloxy]benzoate

生成物 1

HCID 158507574-[2-(N-Benzylimidazol-4-yl)ethyloxy]benzoic acid

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

A mixture of the ester 25-4 (170 mg, 0.51 mmol), CH3OH (10 mL), and 1N NaOH (5 mL) was stirred for 20 hours at ambient temperature. The cooled reaction mixture was acidified with 1N HCl (5 mL) and extracted with EtOAc. The EtOAc portion was concentrated to give 25-5 as a gelataneous solid.

後処理

  1. customThe cooled reaction mixture
  2. extractionextracted with EtOAc
  3. concentrationThe EtOAc portion was concentrated

出典と根拠

ORDレコード
ord-706bd961279a411c84650ee391878fb9
出典データセット
uspto-grants-1997_07
特許番号
US05648368

反応ノート

読み込み中…