Sodium Hydroxide → 2-(3-(Propan-2-yloxy)phenyl)acetic acid

HRID 265942ノート

反応式

HRID 265942 の反応式
C([O:4][C:5](=[O:17])[CH2:6][C:7]1[CH:12]=[CH:11][CH:10]=[C:9]([O:13][CH:14]([CH3:16])[CH3:15])[CH:8]=1)(C)C.[OH-].[Na+]>C(O)C.O>[CH:14]([O:13][C:9]1[CH:8]=[C:7]([CH2:6][C:5]([OH:17])=[O:4])[CH:12]=[CH:11][CH:10]=1)([CH3:16])[CH3:15]

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 54166898Isopropyl 2-(3-isopropoxyphenyl)acetate

生成物 1

HCID 166389242-(3-(Propan-2-yloxy)phenyl)acetic acid

試薬・触媒・溶媒 1

HCID 19096565Water ethanol溶媒

実験手順

Combine 3-isopropoxy-phenyl-acetic acid isopropyl ester 10.2 g, 43.2 mmol) and sodium hydroxide (2.08 g, 51.8 mmol) in 1/1 ethanol/water (80 mL). Heat to reflux. After 18 hours, remove the ethanol by evaporation in vacuo and acidify to pH=1 using an aqueous solution with 1M hydrochloric acid solution. Extract the aqueous solution 3 times with ethyl acetate. Extract the combined organic layers with water and saturated sodium chloride solution. Dry the organic layer over MgSO4, filter, and evaporate in vacuo to obtain 3-isopropoxy-phenyl-acetic acid.

後処理

  1. temperatureHeat to reflux
  2. customremove the ethanol
  3. customby evaporation in vacuo
  4. extractionExtract the aqueous solution 3 times with ethyl acetate
  5. extractionExtract the combined organic layers with water and saturated sodium chloride solution
  6. dry with materialDry the organic layer over MgSO4
  7. filtrationfilter
  8. customevaporate in vacuo

出典と根拠

ORDレコード
ord-f3132e82f4514935909de19963956e85
出典データセット
uspto-grants-1997_07
特許番号
US05648366

反応ノート

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