Oxalyl chloride → 3-Isopropoxy-phenyl-acetyl chloride

HRID 265943ノート

反応式

HRID 265943 の反応式
[CH:1]([O:4][C:5]1[CH:6]=[C:7]([CH2:11][C:12]([OH:14])=O)[CH:8]=[CH:9][CH:10]=1)([CH3:3])[CH3:2].C(Cl)(=O)C([Cl:18])=O>CN(C)C=O.ClCCl>[CH:1]([O:4][C:5]1[CH:6]=[C:7]([CH2:11][C:12]([Cl:18])=[O:14])[CH:8]=[CH:9][CH:10]=1)([CH3:3])[CH3:2]

参加物

5

反応物 2

HCID 65578Oxalyl chlorideHCID 166389242-(3-(Propan-2-yloxy)phenyl)acetic acid

生成物 1

HCID 183334403-Isopropoxy-phenyl-acetyl chloride

試薬・触媒・溶媒 2

HCID 6228Dimethylformamide触媒HCID 6344Dichloromethane溶媒

反応条件

温度
-5 °C

実験手順

Combine 3-isopropoxy-phenyl-acetic acid (0.5 g, 2.6 mmol) and dichloromethane (5 mL). Cool to -5° C. using a ice-salt bath. Add 2 drops of dimethylformamide followed by dropwise addition of oxalyl chloride (0.34 g, 2.7 mmol). after 1 hour, warm the reaction mixture to ambient temperature. After 2 hours, evaporate the reaction mixture in vacuo to give the title compound as a liquid.

後処理

  1. temperaturewarm the reaction mixture to ambient temperature
  2. waitAfter 2 hours
  3. customevaporate the reaction mixture in vacuo

出典と根拠

ORDレコード
ord-3dddf33e95af4c04a8de5680e4ea1b47
出典データセット
uspto-grants-1997_07
特許番号
US05648366

反応ノート

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