Sodium Hydroxide → 2-(Adamantan-2-yl)acetic acid

HRID 266037ノート

反応式

HRID 266037 の反応式
[OH-].[Na+].C[O:4][C:5](=[O:17])[CH2:6][CH:7]1[CH:14]2[CH2:15][CH:10]3[CH2:11][CH:12]([CH2:16][CH:8]1[CH2:9]3)[CH2:13]2>CO>[CH:14]12[CH2:15][CH:10]3[CH2:11][CH:12]([CH2:16][CH:8]([CH2:9]3)[CH:7]1[CH2:6][C:5]([OH:17])=[O:4])[CH2:13]2

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 54117306Methyl 2-adamantylacetate

生成物 1

HCID 8709902-(Adamantan-2-yl)acetic acid

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

Aqueous 2.5 N sodium hydroxide solution 433 ml was added to methanol solution 1125 ml of 2-adamantyl acetic acid methyl ester 150 g (0.72 mol) and stirred at room temperature for 6 hours. Reaction mixture was concentrated in vacuo. Aqueous sodium bicarbonate solution was added to the residue and the mixture was washed with ether. Aqueous layer was adjusted to pH 1 by adding 12 N hydrochloric acid, extracted with ethyl acetate and dried with anhydrous sodium sulfate.

後処理

  1. customReaction mixture
  2. concentrationwas concentrated in vacuo
  3. additionAqueous sodium bicarbonate solution was added to the residue
  4. washthe mixture was washed with ether
  5. additionby adding 12 N hydrochloric acid
  6. extractionextracted with ethyl acetate
  7. dry with materialdried with anhydrous sodium sulfate

出典と根拠

ORDレコード
ord-e83ba4a8905241d5b530a1f2136bebf4
出典データセット
uspto-grants-1997_07
特許番号
US05650406

反応ノート

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