2-Aminopyridine → 2-Methylimidazo[1,2-a]pyridine

HRID 266058

反応式

HRID 266058 の反応式
[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][N:3]=1.[CH3:8][C:9](C1C=CC=C(C2C=CC(CC3C(CCCC)=NN4CCCCC=34)=CC=2)C=1C([O-])=O)(C)[CH3:10].BrCC(=O)C>CC(C)=O>[CH3:10][C:9]1[N:1]=[C:2]2[CH:7]=[CH:6][CH:5]=[CH:4][N:3]2[CH:8]=1

参加物

5

反応物 3

HCID 104392-AminopyridineHCID 11715BromoacetoneHCID 1317201001,1-Dimethylethyl4'-[(2-butyl4,5,6,7-tetrahydro pyrazolo(1,5-a)pyridin-3-yl)methyl](1,1-biphenyl)2-carboxylate

生成物 1

HCID 1367422-Methylimidazo[1,2-a]pyridine収率 245.4%

試薬・触媒・溶媒 1

HCID 180Acetone溶媒2 回

実験手順

A mixture of 5 g of 2-amino pyridine and 250 ml of acetone were added at ambient temperature to a mixture of 7.25 g of 1 bromo 2-propanone and 20 ml of acetone and the mixture was refluxed for 30 minutes. Using the procedure of Stage C of Example 22, 5.3 g of the expected product were obtained in the form of an orange oil.

後処理

  1. temperaturethe mixture was refluxed for 30 minutes

出典と根拠

ORDレコード
ord-62a8dbba62a849dea444fa303423e856
出典データセット
uspto-grants-1997_07
特許番号
US05650414

関連ノート

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